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ea0081rc12.3 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Binding affinity affecting SHBG SNPs do not majorly affect calculated estimates of free testosterone

Walravens Joeri , Banica Thiberiu , Van Den Eynde Tibbert , Snaterse Gido , Reyns Tim , Narinx Nick , Antonio Leen , Fiers Tom , Kaufman Jean-Marc , Lapauw Bruno

Introduction: According to the free hormone transport hypothesis, only free testosterone (FT) is considered biologically active. Due to low circulating levels and technical challenges of direct FT measurements, calculators have been developed to estimate FT from serum total T, sex hormone-binding globulin (SHBG) and albumin levels. However, genetic polymorphisms altering SHBGs binding affinity or capacity might result in calculation imprecisions with consequent incorrect...

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ea0070aep801 | Reproductive and Developmental Endocrinology | ECE2020

11-Ketotestosterone is the Predominant Androgen in Castration Resistant Prostate Cancer

Snaterse Gido , van Dessel Lisanne F , van Riet Job , Taylor Angela E , Visser Jenny A , Arlt Wiebke , Lolkema Martijn P , Hofland Hans

Background: The treatment of metastatic castration-resistant prostate cancer (CRPC) remains dependent on Androgen Receptor (AR) mediated signalling, thus understanding all components involved in testosterone signalling in these men is of utmost importance. Recent studies have identified 11-ketotestosterone (11 KT) as a potent androgen receptor (AR) agonist present in humans. However, it is unknown if 11 KT is present at physiologically relevant concentrations in CRPC patients....

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Endocrine Abstracts

Binding affinity affecting SHBG SNPs do not majorly affect calculated estimates of free testosterone

11-Ketotestosterone is the Predominant Androgen in Castration Resistant Prostate Cancer

BiosciAbstracts